Research display that liquid biopsies have a prime specificity however a low sensitivity. That suggests the blood take a look at may be very correct at figuring out a good end result, however a damaging end result will not be as exact. So in case you obtain a damaging end result, your physician will most likely form a tissue biopsy to verify that the consequences are proper.
Consistent with an editorial printed within the magazine Recovery, some research have proven that the sensitivity of liquid biopsies area from 60 to 85 %. However extra delicate liquid biopsy applied sciences are unexpectedly rising, says Hirsch.
“The amount of DNA in the blood might be dependent on the size of the tumor and the stage,” he says. “Sometimes there is not enough DNA for reliable examination. Sometimes there’s a discrepancy between the molecular findings in the blood and in the tumor.”
Alternative demanding situations and downsides of liquid biopsy, in keeping with the Global Magazine of Molecular Sciences, come with refer to:
- There isn’t a standardized process and protocol for medical doctors to virtue liquid biopsy within the medical environment, which is a consider a rarity of popular availability; that during flip makes it tougher to have cast research to decide which requirements and protocols paintings perfect.
- Some biomarkers are fragile, which means that they’re at prime possibility of turning into unusable sooner than research.
- Some molecules are simplest to be had in low concentrations in frame fluid, making it tricky to isolate and analyze those biomarkers.
